warn about a possibly serious interaction between calcium channel blockers and macrolide antibiotics
March 2011
You'll hear Canadian researchers warn about a possibly serious interaction between calcium channel blockers and macrolide antibiotics.
Clarithromycin and erythromycin are CYP3A4 inhibitors and therefore can inhibit the metabolism of calcium channel blockers.
This can boost serum levels of the calcium channel blocker...and possibly increase its effects. For example, erythromycin more than DOUBLES levels of felodipine.
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